Is it possible to develop a 'universal' influenza vaccine?
Identifieur interne : 000179 ( Main/Exploration ); précédent : 000178; suivant : 000180Is it possible to develop a 'universal' influenza vaccine?
Auteurs : James E. CroweSource :
- Cold Spring Harbor perspectives in biology [ 1943-0264 ] ; 2018.
Abstract
Development of optimal vaccines for influenza is challenging, in part due to the high antigenic variability in field strains associated with genetic shift from reassortment and genetic drift from point mutations. Discovery of conserved antigenic sites on the hemagglutinin (HA) protein for neutralizing antibodies suggested the possibility that influenza vaccines could be developed that induce focused antibody responses to the conserved neutralizing determinants, especially the HA stem region. Recent studies have focused on the antigenicity and immunogenicity of such domains, using monoclonal antibodies and candidate engineered HA stem-based vaccines. Much progress has been made, but we still do not fully understand the biology of the immune response to this unique antigenic region.
Url:
DOI: 10.1101/cshperspect.a029496
PubMed: 28663208
PubMed Central: 5829045
Affiliations:
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